The Effect Of Two Multicomponent Lifestyle Interventions...

The objective of the PREMIER research was to study the effect of two multicomponent lifestyle interventions on estimated coronary heart disease (CHD) risk compared to advice alone intervention.1 The study also evaluated whether the differences can be detected in the effects of the lifestyle interventions among subgroups defined by baseline variables.1 The results from the study can help future researches to focus on the intervention that has proven to be effective in reducing the heart disease risk. The PREMIER study was a National Heart, Lung, and Blood Institute (NHLBI) sponsored, multicenter, 3-group, parallel-arm randomized trial conducted in the United States.1 For the study, a total of 810, of which 62% were women and 34% were black, healthy adults with untreated prehypertension or stage 1 hypertension who met the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure criteria for a 6-month trial of nonpharmacological BP treatment, were recruited.1 The participants were randomized to 1 of 3 intervention groups: An â€Å"advice-only† group, an â€Å"established† group (EST) that used established lifestyle recommendations for blood pressure control (reduced sodium intake, weight loss, and increased physical activity), or an â€Å"established-plus-DASH† group (EST+DASH) that combined established lifestyle changes with the DASH (Dietary Approaches to Stop Hypertension) diet.1 The mean age of the participants were 50 years, the mean systolic/diastolic